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KMID : 0356920120630050436
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Korean Journal of Anesthesiology
2012 Volume.63 No. 5 p.436 ~ p.440
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Does dexmedetomidine reduce postoperative pain after laparoscopic cholecystectomy with multimodal analgesia?
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Park Jung-Kyu
Cheong Soon-Ho
Lee Kun-Moo
Lim Se-Hun
Lee Jeong-Han
Cho Kwang-Rae
Kim Myoung-Hun
Kim Hyun-Tae
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Abstract
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Background: Pain after laparoscopy is multifactorial and different treatments have been proposed to provide pain relief. Multimodal analgesia is now recommended to prevent and treat post-laparoscopy pain. Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We evaluated the analgesic effect of perioperative dexmedetomidine infusion during laparoscopic cholecystectomy with multimodal analgesia.
Methods: Forty-two patients aged 20 to 60 years old were allocated randomly into one of 2 groups (n = 21, in each). All patients underwent laparoscopic cholecystectomy under multimodal analgesia. The patients in group P received dexmedetomidine 1 μg/kg during 10 min before induction and then 0.5 μg/kg/h continuously until the removal of the gall bladder while the patients in the group C received saline by the same methods as group P. Total analgesic consumption and VAS score were recorded for the first 24 hr.
Results: There were no significant differences in VAS scores between group P and group C during 24 hr after laparoscopic cholecystectomy. VAS scores of group P were lower than that of group C during the 1st hr after operation. The amount of ketorolac required during the 24 hr after the operation was significantly less in group P compared to group C.
Conclusions: The administration of dexmedetomidine during laparoscopic cholecystectomy with multimodal analgesia has minimal benefits on the reduction of the postoperative pain score. The amount of ketorolac requirements during 24 hr after the operation showed significant difference. Dexmedetomidine might be helpful for the postoperative pain after laparoscopic cholecystectomy with multimodal analgesia.
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KEYWORD
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Dexmedetomidine, Laparoscopic cholecystectomy, Postoperative pain
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